Title of article
Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase
Author/Authors
Peter Jan Zimmermann، نويسنده , , Wilm Buhr، نويسنده , , Christof Brehm، نويسنده , , Andreas Marc Palmer، نويسنده , , Martin Philipp Feth، نويسنده , , J?rg Senn-Bilfinger، نويسنده , , Wolfgang-Alexander Simon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5374
To page
5378
Abstract
A series of novel 8-indanylamino- and 8-indanyloxy-substituted imidazo[1,2-a]pyridines with reduced lipophilicity was synthesized from easily accessible starting compounds. The anti-secretory activity of these compounds has been assessed in a competitive binding assay against H+/K+-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.
Keywords
H+/K+-ATPase , 2-a]pyridine , Anti-ulcer , Gastric acid inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798617
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