Title of article
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors
Author/Authors
Wenge Zhong، نويسنده , , Hu Liu، نويسنده , , Matthew R. Kaller، نويسنده , , Charles Henley، نويسنده , , Ella Magal، نويسنده , , Thomas Nguyen، نويسنده , , Timothy D. Osslund، نويسنده , , David Powers، نويسنده , , Robert M. Rzasa، نويسنده , , Hui-Ling Wang، نويسنده , , Weiya Wang، نويسنده , , Xiaoling Xiong، نويسنده , , Jiandong Zhang، نويسنده , , Mark H. Norman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5384
To page
5389
Abstract
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase and its deregulation is implicated in a number of neurodegenerative disorders such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. Using active site homology modeling between CDK5 and CDK2, we explored several different chemical series of potent CDK5 inhibitors. In this report, we describe the design, synthesis, and CDK5 inhibitory activities of quinolin-2(1H)-one derivatives.
Keywords
kinase , Neurodegenerative disorders , CDK5 inhibitor , quinolin-2(1H)-one
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798619
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