Title of article
Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists
Author/Authors
John A. Wendt، نويسنده , , Susan D. Deeter، نويسنده , , Susan E. Bove، نويسنده , , Christopher S. Knauer، نويسنده , , Rachel M. Brooker، نويسنده , , Corinne E. Augelli-Szafran، نويسنده , , Roy D. Schwarz، نويسنده , , Jack J. Kinsora، نويسنده , , Kenneth S. Kilgore، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
5396
To page
5399
Abstract
A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.
Keywords
SAR , arthritis , rat , mGlu5 receptor antagonist , 3-d]pyrimidine , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798621
Link To Document