Title of article :
Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai
Author/Authors :
Hiroshi Morita، نويسنده , , Maiko Enomoto، نويسنده , , Yusuke Hirasawa، نويسنده , , Toru Iizuka، نويسنده , , Kazunori Ogawa، نويسنده , , Nobuo Kawahara، نويسنده , , Yukihiro Goda، نويسنده , , Teruki Matsumoto، نويسنده , , Koichi Takeya، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A new cyclic heptapeptide, cyclonatsudamine A (1), cyclo (-Gly-Tyr-Leu-Leu-Pro-Pro-Ser-), has been isolated from the peels of Citrus natsudaidai and the structure was elucidated by 2D NMR analysis and chemical degradation. Cyclonatsudamine A (1) relaxed norepinephrine-induced contractions of rat aorta, which may be mediated through the increased release of NO from endothelial cells.
Keywords :
vasodilator , Citrus natsudaidai , Cyclic heptapeptide , Cyclonatsudamine A
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
