Author/Authors :
Yuhpyng L. Chen، نويسنده , , Kevin Cherry، نويسنده , , Michael L. Corman، نويسنده , , Charles F. Ebbinghaus، نويسنده , , Chandra B. Gamlath، نويسنده , , Dane Liston، نويسنده , , Barbara-Anne Martin، نويسنده , , Christine E. Oborski، نويسنده , , Barbara G. Sahagan، نويسنده ,
Abstract :
The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of <0.3 nM. The synthesis and SAR, as well as a radiolabeled synthesis of [3H]-2a, are described.
