Title of article
Structure–activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation
Author/Authors
YOSHIHIRO MATSUDA AND MAKOTO KAWAI، نويسنده , , Isao Sakurada، نويسنده , , Asato Morita، نويسنده , , Yuko Iwamuro، نويسنده , , Kazuo Ando، نويسنده , , Hirofumi Omura، نويسنده , , Sachiko Sakakibara، نويسنده , , Tsutomu Masuda، نويسنده , , Hiroki Koike، نويسنده , , Teruki Honma، نويسنده , , Kazunari Hattori، نويسنده , , Tadayuki Takashima، نويسنده , , Kunihiko Mizuno، نويسنده , , Mayumi Mizutani، نويسنده , , and Mitsuhiro Kawamura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5537
To page
5542
Abstract
A novel potent NMDA-NR2B selective antagonist (5b) without the reactive metabolites formation issue was identified. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.
Keywords
Reactive metabolite , NR2B , bioactivation , NMDA , Metabolic stability
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798649
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