Title of article :
Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis
Author/Authors :
Shu-Wei Yang، نويسنده , , Tze-Ming Chan، نويسنده , , Alexei Buevich، نويسنده , , Tony Priestley، نويسنده , , James Crona، نويسنده , , John Reed، نويسنده , , Amy E. Wright، نويسنده , , Mahesh Patel، نويسنده , , Vincent Gullo، نويسنده , , Guodong Chen، نويسنده , , Birendra Pramanik، نويسنده , , Min Chu، نويسنده ,
Abstract :
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC50 of 9 μM. The purification and the structure elucidation of these two saponins are described.
Keywords :
NaV1.8 sodium channel , starfish , Saponin , Sch 725737 , Sch 725739 , Novodinia antillensis
