Title of article
On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition
Author/Authors
Victor Gonçalves، نويسنده , , Benoit Gautier، نويسنده , , Anne Regazzetti، نويسنده , , Pascale Coric، نويسنده , , Serge Bouaziz، نويسنده , , Christiane Garbay، نويسنده , , Michel Vidal، نويسنده , , Nicolas Inguimbert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5590
To page
5594
Abstract
Cyclic peptides were obtained, on-resin, by the copper (I) catalysed 1,3-dipolar cycloaddition of azides and alkynes. The reaction led exclusively to the formation of the expected cyclomonomeric products which acted as ligands of the Vascular Endothelial Growth Factor receptor 1.
Keywords
click chemistry , Huisgen reaction , Antagonist , VEGF receptors , Resin supported synthesis , Cyclic peptide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798660
Link To Document