Author/Authors :
Joseph H. Krushinski Jr.، نويسنده , , John M. Schaus، نويسنده , , Dennis C. Thompson، نويسنده , , David O. Calligaro، نويسنده , , Albert L. Lehninger, David L. Nelson, Michael M. Cox، نويسنده , , Susan H. Luecke، نويسنده , , David B. Wainscott، نويسنده , , David T. Wong، نويسنده ,
Abstract :
Analogues of pindolol, 1-(1H-indol-4-yloxy)-3-isopropylamino-propan-2-ol, were synthesized and evaluated as 5-HT1A receptor antagonists. The structural features required for optimal binding to the 5-HT1A receptor are as follows: S-2-propanol linker, 4-indoloxy substituent, and a large lipophilic cyclic amine substituent.
