Title of article
Indoloxypropanolamine analogues as 5-HT1A receptor antagonists
Author/Authors
Joseph H. Krushinski Jr.، نويسنده , , John M. Schaus، نويسنده , , Dennis C. Thompson، نويسنده , , David O. Calligaro، نويسنده , , Albert L. Lehninger, David L. Nelson, Michael M. Cox، نويسنده , , Susan H. Luecke، نويسنده , , David B. Wainscott، نويسنده , , David T. Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5600
To page
5604
Abstract
Analogues of pindolol, 1-(1H-indol-4-yloxy)-3-isopropylamino-propan-2-ol, were synthesized and evaluated as 5-HT1A receptor antagonists. The structural features required for optimal binding to the 5-HT1A receptor are as follows: S-2-propanol linker, 4-indoloxy substituent, and a large lipophilic cyclic amine substituent.
Keywords
Serotonin , 5-HT1A antagonist , Pindolol
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798662
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