Title of article
Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents
Author/Authors
Aman Mahajan، نويسنده , , Susan Yeh، نويسنده , , Margo Nell، نويسنده , , Constance E.J. van Rensburg، نويسنده , , Kelly Chibale، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
3
From page
5683
To page
5685
Abstract
New 7-chloroquinolinyl thiourea derivatives derived from the corresponding 4,7-dichloroquinoline isothiocyanate were synthesized and evaluated for in vitro antimalarial and anticancer activity. The most active compound from the series displayed an inhibitory IC50 value of 1.2 μM against the D10 strain of Plasmodium falciparum. Lack of cytotoxicity towards HeLa cells indicates selectivity towards parasites.
Keywords
4-Quinolyl isothiocyanate , 7-Chloroquinolinyl thioureas , Human adenocarcinoma of the cervix , Plasmodium falciparum
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798679
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