Title of article :
Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases
Author/Authors :
Xiaoan Wen، نويسنده , , Jun Xia، نويسنده , , Keguang Cheng، نويسنده , , Liying Zhang، نويسنده , , Pu Zhang، نويسنده , , Jun Liu، نويسنده , , Luyong Zhang، نويسنده , , Peizhou Ni، نويسنده , , Hongbin Sun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The synthesis and biological evaluation of corosolic acid derivatives and related compounds as inhibitors of rabbit muscle glycogen phosphorylase a is described. Within this series of compounds, 8 (IC50 = 7.31 μM), 12d (IC50 = 3.26 μM), and 12e (IC50 = 5.1 μM) exhibited more potent activities than the parent compound 1 (IC50 = 20 μM). SAR of these compounds is also discussed.
Keywords :
Corosolic acid , glycogen phosphorylase , derivatives , inhibitor , synthesis , SAR
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
