Title of article
Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases
Author/Authors
Xiaoan Wen، نويسنده , , Jun Xia، نويسنده , , Keguang Cheng، نويسنده , , Liying Zhang، نويسنده , , Pu Zhang، نويسنده , , Jun Liu، نويسنده , , Luyong Zhang، نويسنده , , Peizhou Ni، نويسنده , , Hongbin Sun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5777
To page
5782
Abstract
The synthesis and biological evaluation of corosolic acid derivatives and related compounds as inhibitors of rabbit muscle glycogen phosphorylase a is described. Within this series of compounds, 8 (IC50 = 7.31 μM), 12d (IC50 = 3.26 μM), and 12e (IC50 = 5.1 μM) exhibited more potent activities than the parent compound 1 (IC50 = 20 μM). SAR of these compounds is also discussed.
Keywords
Corosolic acid , glycogen phosphorylase , derivatives , inhibitor , synthesis , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798696
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