Author/Authors :
Madhavi Pannala، نويسنده , , Sunil Kher، نويسنده , , Norma Wilson، نويسنده , , John Gaudette، نويسنده , , Ila Sircar، نويسنده , , Shao-Hui Zhang، نويسنده , , Alexei Bakhirev، نويسنده , , Guang Yang، نويسنده , , Phoebe Yuen، نويسنده , , Frank Gorcsan، نويسنده , , Naoki Sakurai، نويسنده , , Miguel Barbosa، نويسنده , , Jie-Fei Cheng، نويسنده ,
Abstract :
Synthesis and structure–activity relationship of a series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitrile derivatives as EGFR inhibitors is described. Compounds 29 and 30 showed potent in vitro inhibitory activity in the enzymatic assay as well as in the functional cellular assay. They are moderately selective against other types of tyrosine kinases.
