Title of article
Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists
Author/Authors
Dramane I. Lainé، نويسنده , , Haibo Xie، نويسنده , , Noémie Buffet، نويسنده , , James J. Foley، نويسنده , , Peter Buckley، نويسنده , , Edward F. Webb، نويسنده , , Katherine L. Widdowson، نويسنده , , Michael R. Palovich، نويسنده , , Kristen E. Belmonte، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6066
To page
6069
Abstract
In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure–activity relationships and pharmacological evaluation that led to the identification of compound 5o, are described.
Keywords
Quaternary , Antagonists , Muscarinic , Salts , ammonium
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798746
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