Title of article
Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase
Author/Authors
Yongge Qiu، نويسنده , , Jinbo Gao، نويسنده , , Yue-Fei Guo، نويسنده , , Yuqin Qiao، نويسنده , , Ding Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6164
To page
6168
Abstract
Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.
Keywords
Mevalonate 5-diphosphate decarboxylase , Substrate analog , mutation , cardiovascular disease , cholesterol , cancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798767
Link To Document