Title of article :
Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes
Author/Authors :
Martijn Verdoes، نويسنده , , Ulrik Hillaert، نويسنده , , Bogdan I. Florea، نويسنده , , Myra Sae-Heng، نويسنده , , Martijn D.P. Risseeuw، نويسنده , , Dmitri V. Filippov، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Herman S. Overkleeft، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.
Keywords :
Fluorophore , inhibitor , Proteasome , Bioconjugate
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
