Title of article
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
Author/Authors
Michael P. Dwyer، نويسنده , , Kamil Paruch، نويسنده , , Carmen Alvarez-Lorenzo، نويسنده , , Ronald J. Doll، نويسنده , , Kerry Keertikar، نويسنده , , Jose Duca، نويسنده , , Thierry O. Fischmann، نويسنده , , Alan Hruza، نويسنده , , Vincent Madison، نويسنده , , Emma Lees، نويسنده , , David Parry، نويسنده , , Wolfgang Seghezzi، نويسنده , , Nicole Sgambellone، نويسنده , , Frances Shanahan، نويسنده , , Derek Wiswell، نويسنده , , Timothy J. Guzi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6216
To page
6219
Abstract
A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the in-vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors.
Keywords
5-a]pyrimidine , CDK2 , Kinase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798778
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