Title of article
Discovery of 5-HT6 receptor ligands based on virtual HTS
Author/Authors
Stefan Tasler، نويسنده , , Jürgen Kraus، نويسنده , , Andreas Wuzik، نويسنده , , Oliver Müller، نويسنده , , Andrea Aschenbrenner، نويسنده , , Elena Cubero، نويسنده , , Rosalia Pascual، نويسنده , , Jordi-Ramon Quintana-Ruiz، نويسنده , , Alberto Dordal، نويسنده , , Ramon Mercè، نويسنده , , Xavier Codony، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
6224
To page
6229
Abstract
Based on a pharmacophore alignment on a 5-HT6 ligand applying 4SCan® technology, a new lead series was identified and further structurally investigated. Kis down to 8 nM were achieved.
Keywords
GPCR , Molecular modeling , vHTS , Serotonin receptor , 5-HT6
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798780
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