Title of article
Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro
Author/Authors
Yan-bo Tang، نويسنده , , Zong-gen Peng، نويسنده , , Zong-ying Liu، نويسنده , , Yan-ping Li، نويسنده , , Jiandong Jiang، نويسنده , , Zhuo-rong Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6350
To page
6353
Abstract
A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent antiviral agents. The antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of PMEA 5g exhibited potent antiviral activities. The IC50 of 5f for HBV was 2.15 μM, and the IC50 of 5g for HIV-1 was 1.61 μM.
Keywords
Nucleotide prodrugs , antiviral , HIV-1 , HBV
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798805
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