Title of article :
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids
Author/Authors :
Bhahwal A. Shah، نويسنده , , Ajay Kumar، نويسنده , , Pankaj Gupta، نويسنده , , Madhunika Sharma، نويسنده , , Vijay K. Sethi، نويسنده , , Ajit K. Saxena، نويسنده , , Jaswant Singh، نويسنده , , Ghulam N. Qazi، نويسنده , , Subhash C. Taneja، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
4-Amino analogues prepared from β-boswellic acid and 11-keto-β-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
Keywords :
11-Keto-?-boswellic acid , Amino analogues , Epimers , cytotoxicity , DNA fragmentation , ?-Boswellic acid
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
