Author/Authors :
Danielle K. Neff، نويسنده , , Alice Lee-Dutra، نويسنده , , Jonathan M. Blevitt، نويسنده , , Frank U. Axe، نويسنده , , Michael D. Hack، نويسنده , , Johnathan C. Buma، نويسنده , , Raymond Rynberg، نويسنده , , Anders Brunmark، نويسنده , , Lars Karlsson، نويسنده , , J. Guy Breitenbucher، نويسنده ,
Abstract :
A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.
Keywords :
Chk2 , Cds1 , Aminoalcohol , Solubility , Mitsunobu
