Title of article :
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists
Author/Authors :
Clementina Manera، نويسنده , , Maria Grazia Cascio، نويسنده , , Veronica Benetti، نويسنده , , Marco Allarà، نويسنده , , Tiziano Tuccinardi، نويسنده , , Adriano Martinelli، نويسنده , , Giuseppe Saccomanni، نويسنده , , Elisa Vivoli، نويسنده , , Carla Ghelardini، نويسنده , , Vincenzo Di Marzo، نويسنده , , Pier Luigi Ferrarini، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
Keywords :
Cannabinoid , CB1 receptor , CB2 receptor , 1 , 8-Naphthyridine , Quinoline
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
