Author/Authors :
Zhong Zhao، نويسنده , , Gian Luca Araldi، نويسنده , , Yufang Xiao، نويسنده , , Adulla P. Reddy، نويسنده , , Yihua Liao، نويسنده , , Srinivasa Karra، نويسنده , , Nadia Brugger، نويسنده , , David Fischer، نويسنده , , Elizabeth Palmer، نويسنده ,
Abstract :
Replacement of the hydroxy cyclopentanone ring in PGE2 with chemically more stable heterocyclic rings and substitution of the unsaturated α-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE2. Compound 10f showed the highest potency and selectivity for EP4 the receptor.
Keywords :
Prostaglandin , EP2 , EP4 , agonist
