Author/Authors :
Byung Seok Moon، نويسنده , , Moon-Taek Park، نويسنده , , Jeong Hoon Park، نويسنده , , Sang-Wook Kim، نويسنده , , Kyo Chul Lee، نويسنده , , Gwang Il Kim، نويسنده , , Seung Dae Yang، نويسنده , , Dae Yoon Chi، نويسنده , , Gi-Jeong Cheon، نويسنده , , Su-Jae Lee، نويسنده ,
Abstract :
Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
Keywords :
Radiosensitizer , sphingolipids , Phytoceramide , Phytosphingosine
