Title of article
Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives
Author/Authors
Sanjay K. Srivastava، نويسنده , , Manu Jaggi، نويسنده , , Anu T. Singh، نويسنده , , Alka Madan، نويسنده , , Nidhi Rani، نويسنده , , Manupriya Vishnoi، نويسنده , , Shiv K. Agarwal، نويسنده , , Rama Mukherjee، نويسنده , , Anand C. Burman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6660
To page
6664
Abstract
Several 1,8-naphthyridine-3-carboxamide derivatives (8–23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC50 = 1.37 μM) in HBL-100 (breast) cell line while compounds 17 (IC50 = 3.7 μM) and 22 (IC50 = 3.0 μM) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells.
Keywords
Anticancer , anti-inflammatory , Naphthyridine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798865
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