Author/Authors :
Julian Blagg، نويسنده , , Charlotte M.N. Allerton، نويسنده , , David V.J. Batchelor، نويسنده , , Andrew D. Baxter، نويسنده , , Denise J. Burring، نويسنده , , Christopher L. Carr، نويسنده , , Andrew S. Cook، نويسنده , , Carly L. Nichols، نويسنده , , Joanne Phipps، نويسنده , , Vivienne G. Sanderson، نويسنده , , Hugh Verrier، نويسنده , , Stephen Wong، نويسنده ,
Abstract :
This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fold functional selectivity and has been successfully progressed in vivo using an intranasal delivery route.
Keywords :
synthesis , Arylmorpholine , Intranasal delivery , Dopamine D3 receptor agonist
