Title of article
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists
Author/Authors
Jay M. Matthews، نويسنده , , Xiaoli Chen، نويسنده , , Ellen Cryan، نويسنده , , Dennis J. Hlasta، نويسنده , , Philip J. Rybczynski، نويسنده , , Kim Strauss، نويسنده , , Yuting Tang، نويسنده , , June Z. Xu، نويسنده , , Maria Yang، نويسنده , , Lubing Zhou، نويسنده , , Keith T. Demarest، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
6773
To page
6778
Abstract
A series of aminoindane derivatives were synthesized and shown to be potent PPARα agonists. The compounds were obtained as racemates in 12 steps, and tested for PPARα activation and PPARα mediated induction of the HD gene. SAR was developed by variation to the core structure as shown within. Oral bioavailability was demonstrated in a Sprague–Dawley rat, while efficacy to reduce plasma triglycerides and plasma glucose was demonstrated in db/db mice.
Keywords
Hypolipidemic , Aminoindane , hypoglycemic , dyslipidemia , PPAR? agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798884
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