Title of article
Synthesis and evaluation of novel heterocyclic MMP inhibitors
Author/Authors
Ryuji Hayashi، نويسنده , , Xiaomin Jin، نويسنده , , Gregory R. Cook، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
6864
To page
6870
Abstract
A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.
Keywords
Matrix metalloproteinase inhibitors , Pyridinones , bis-Heterocycles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798901
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