Author/Authors :
Baihua Hu، نويسنده , , Elaine Quinet، نويسنده , , Rayomand Unwalla، نويسنده , , Mike Collini، نويسنده , , James Jetter، نويسنده , , Rebecca Dooley، نويسنده , , Diane Andraka، نويسنده , , Lisa Nogle، نويسنده , , Dawn Savio، نويسنده , , Anita Halpern، نويسنده , , Annika Goos-Nilsson، نويسنده , , Anna Wilhelmsson، نويسنده , , Ponnal Nambi، نويسنده , , Jay Wrobel، نويسنده ,
Abstract :
A series of potent and binding selective LXRβ agonists was developed using the previously reported non-selective LXR ligand WAY-254011 as a structural template. With the aid of molecular modeling, it was found that 2,3-diMe-Ph, 2,5-diMe-Ph, and naphthalene substituted quinoline acetic acids (such as quinoline 33, 37, and 38) showed selectivity for LXRβ over LXRα in binding assays.
Keywords :
LXR agonists , Quinolines , Carboxylic acids , Selectivity in binding assays
