Title of article
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Author/Authors
Luigi Scipione، نويسنده , , Daniela De Vita، نويسنده , , Alessandra Musella، نويسنده , , Lisa Flammini، نويسنده , , Simona Bertoni، نويسنده , , Elisabetta Barocelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
309
To page
312
Abstract
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
Keywords
4-Aminopyridine derivatives , Acetylcholinesterase , Butyrylcholinesterase , Antiamnesic effects
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798969
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