Title of article :
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode
Author/Authors :
Richard M. Angell، نويسنده , , Paul Bamborough، نويسنده , , Anne Cleasby، نويسنده , , Stuart G. Cockerill، نويسنده , , Katherine L. Jones، نويسنده , , Christopher J. Mooney، نويسنده , , Donald O. Somers، نويسنده , , Ann L. Walker، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
Keywords :
Focused screen , Virtual screening , structure-based drug design , p38 kinase , Kinase selectivity , p38 alpha , CSBP , MAP kinase , Biphenyl amide , inhibitors , BPA , Biphenyl amides , BPAs , Protein kinase X-ray structure , binding mode , Pharmacophore search , p38
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
