Title of article :
Design, synthesis, and studies of small molecule STAT3 inhibitors
Author/Authors :
Deepak Bhasin، نويسنده , , Katryna Cisek، نويسنده , , Trupti Pandharkar، نويسنده , , Nicholas Regan، نويسنده , , Chenglong Li، نويسنده , , Bulbul Pandit، نويسنده , , Jiayuh Lin، نويسنده , , Pui-Kai Li، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A series of small molecule STAT3 inhibitors originally derived from our lead compound STA 21 were synthesized and evaluated. The most potent compound in this series, compound 1, exhibited the same anti-proliferative activities as STA 21 against prostate cancer cell lines that express constitutively active STAT3. Molecular docking showed compound 1 bound to the STAT3β SH2 domain in a similar manner as STA 21.
Keywords :
STAT3 inhibitors , Transcription factor , STA 21 , prostate cancer
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
