Author/Authors :
Pierre Verhaeghe، نويسنده , , Nadine Azas، نويسنده , , Monique Gasquet، نويسنده , , Sébastien Hutter، نويسنده , , Christophe Ducros، نويسنده , , Michèle Laget، نويسنده , , Sylvain Rault، نويسنده , , Pascal Rathelot، نويسنده , , Patrice Vanelle، نويسنده ,
Abstract :
A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodium falciparum strains, and the selectivity indexes for THP1 and HepG2 human cells were also calculated, revealing their antiplasmodial potential.
Keywords :
Quinazoline , Microwave-assisted chemistry , Suzuki-Miyaura cross-coupling reaction , malaria
