Author/Authors :
Carl P. Bergstrom، نويسنده , , Charles P. Sloan، نويسنده , , Wai-Yu Lau، نويسنده , , David W. Smith، نويسنده , , Ming Zheng، نويسنده , , Steven B. Hansel، نويسنده , , Craig T. Polson، نويسنده , , Jason A. Corsa، نويسنده , , Donna M. Barten، نويسنده , , Kevin M. Felsenstein، نويسنده , , Susan B. Roberts، نويسنده ,
Abstract :
The synthesis and γ-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Aβ in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2.
Keywords :
Amyloid-? , sulfonamides , Alzheimer’s Disease , Secretase
