Title of article
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide
Author/Authors
Alessandro Piergentili، نويسنده , , Wilma Quaglia، نويسنده , , Mario Giannella، نويسنده , , Fabio Del Bello، نويسنده , , Michela Buccioni، نويسنده , , Marta Nesi، نويسنده , , Rosanna Matucci، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
614
To page
618
Abstract
Two stereoselective parallel divergent four-step procedures to obtain all four enantiomeric forms of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide were developed. Enantiomeric purity was determined by quantitative 1H NMR spectroscopy in the presence of the chiral shift reagent (+)-MTPA. The biological profile of the obtained compounds was evaluated at all muscarinic receptor subtypes by binding and functional assays.
Keywords
Receptor enantioselectivity , Stereoselective synthesis , Muscarinic Receptors , muscarinic agonists , 1 , 4-Dioxane nucleus , Subtype selectivity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799025
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