Title of article :
Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate
Author/Authors :
Honglu Zhang، نويسنده , , Yong Xu، نويسنده , , Nicolas Markadieu، نويسنده , , Renaud Beauwens، نويسنده , , Christophe Erneux، نويسنده , , Glenn D. Prestwich، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells.
Keywords :
PtdIns(3 , 5)P3 , asymmetric synthesis , Activating sodium transport , Metabolically-stabilized , 4
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
