Title of article :
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: Design, synthesis, and SAR studies
Author/Authors :
Caroline Meyers، نويسنده , , Matilde Y??ez، نويسنده , , Abdelaziz Elmaatougi، نويسنده , , Tom Verhelst، نويسنده , , Alberto Coelho، نويسنده , , Nuria Fraiz، نويسنده , , Guy L.F. Lemière، نويسنده , , Xerardo Garc?´a-Mera، نويسنده , , Reyes Laguna، نويسنده , , Ernesto Cano، نويسنده , , Bert U.W. Maes، نويسنده , , Eddy Sotelo، نويسنده ,
Abstract :
A set of regioisomeric 2-substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl fragment at either position 4, 5 or 6 and 2-substituted pyridazin-3(2H)-ones containing the same fragment both at positions 4 and 5 have been synthesized and evaluated as antiplatelet agents. The study allows the identification of a new highly potent platelet aggregation inhibitor (4c).
Keywords :
chalcones , pyridazinones , Platelets , antiplatelet agents
