Title of article
Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist
Author/Authors
Yufang Xiao، نويسنده , , Gian Luca Araldi، نويسنده , , Zhong Zhao، نويسنده , , Adulla Reddy، نويسنده , , Srinivasa Karra، نويسنده , , Nadia Brugger، نويسنده , , David Fischer، نويسنده , , Elizabeth Palmer، نويسنده , , Bagna Bao، نويسنده , , Sean D. Mckenna، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
821
To page
824
Abstract
γ-Lactam analogs (2) of EP4 receptor agonists were identified by substitution of the pyrazolidinone ring (1) with a pyrrolidinone ring. Several compounds (such as 2a, 2h) with high potency, selectivity and acceptable PK profiles were discovered. These were assessed in animal models of ovulation induction and bronchoconstriction.
Keywords
EP4 receptor , EP2 receptor , Prostaglandin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799067
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