Title of article :
Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4′-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology
Author/Authors :
Rosaleen J. Anderson، نويسنده , , Paul W. Groundwater، نويسنده , , Yongxue Huang، نويسنده , , Arthur L. James، نويسنده , , Sylvain Orenga، نويسنده , , Annette Rigby، نويسنده , , Céline Roger-Dalbert، نويسنده , , John D. Perry، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The synthesis and initial evaluation of novel chromogenic substrates with potential in the detection and differentiation of cultured bacterial colonies are described. The substrates were readily hydrolysed by specific aminopeptidase activity to release the chromogen, 9-(4′-aminophenyl)-10-methylacridinium salt, which provided a clear visual indication of the presence of the corresponding bacteria.
Keywords :
Diagnostic reagent , Clinical bacteriology , 9-(4?-Aminophenyl)-10-methylacridinium salt , alanine aminopeptidase , Chromogenic peptidase substrate , ?-Alanine aminopeptidase , cystic fibrosis , Microorganism differentiation , Microorganism detection
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
