Title of article
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity
Author/Authors
Neeraj Mahindroo، نويسنده , , Chandanamali Punchihewa، نويسنده , , Allison M. Bail، نويسنده , , Naoaki Fujii، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
946
To page
949
Abstract
We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcription activated by exogenous Dvl via the biochemical antagonism. We confirmed tumor cell-selective activation of caspases by these compounds.
Keywords
PDZ domain , Apoptosis , Indole , Anti-cancer , TCF , WNT , Dishevelled
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799090
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