Title of article
Targeting ACE and ECE with dual acting inhibitors
Author/Authors
Stephen Hanessian، نويسنده , , Sébastien Guesné، نويسنده , , Ludivine Riber، نويسنده , , Julien Marin، نويسنده , , Alain Benoist، نويسنده , , Philippe Mennecier، نويسنده , , Alain Rupin، نويسنده , , Tony J. Verbeuren، نويسنده , , Guillaume De Nanteuil، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
1058
To page
1062
Abstract
A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.
Keywords
SA6817 analogues , Dual ECE–ACE enzyme inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799113
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