Title of article :
A graftable LDV peptidomimetic: Design, synthesis and application to a blood filtration membrane
Author/Authors :
Maryam Momtaz، نويسنده , , Vincent Rerat، نويسنده , , Sonia Gharbi، نويسنده , , Estelle Gérard، نويسنده , , Vincent Pourcelle، نويسنده , , Jacqueline Marchand-Brynaert، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenyl-propionic acid, as α4β1 (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention.
Keywords :
?4?1 integrin ligand , LDV peptidomimetic , PVDF filter , Leukocyte depletion , Surface wet chemistry
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
