Title of article
N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR
Author/Authors
Holly L. Deak، نويسنده , , John R. Newcomb، نويسنده , , Joseph J. Nunes، نويسنده , , Christina Boucher، نويسنده , , Alan C. Cheng، نويسنده , , Erin F. DiMauro، نويسنده , , Linda F. Epstein، نويسنده , , Paul Gallant، نويسنده , , Brian L. Hodous، نويسنده , , Xin Huang، نويسنده , , Josie H. Lee، نويسنده , , Vinod F. Patel، نويسنده , , Stephen Schneider، نويسنده , , Susan M. Turci، نويسنده , , Xiaotian Zhu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
1172
To page
1176
Abstract
N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure–activity relationships, and the synthesis of these inhibitors are reported herein.
Keywords
Lck inhibitor , kinase inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799135
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