Title of article
Discovery of a novel class of selective human CB1 inverse agonists
Author/Authors
Nicolas Foloppe and Lennart Nilsson، نويسنده , , Nicola H. Allen، نويسنده , , Carol H. Bentley، نويسنده , , Teresa D. Brooks، نويسنده , , Guy Kennett، نويسنده , , Antony R. Knight، نويسنده , , Stefania Leonardi، نويسنده , , Anil Misra، نويسنده , , Nathaniel J.T. Monck، نويسنده , , Daniel M. Sellwood، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
1199
To page
1206
Abstract
Ligand-based virtual screening led to the discovery of a new class of potent inverse agonists of the human cannabinoid receptor 1, hCB1, which are selective versus hCB2. These CB1 ligands present intriguing departures from a classical CB1 antagonist pharmacophore. Elements of SAR are discussed in this context.
Keywords
obesity , Virtual screening , Pharmacophore , Drug design , Cannabinoids
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799139
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