Author/Authors :
Fujiko Konno، نويسنده , , Takuya Arai، نويسنده , , Ming-Rong Zhang، نويسنده , , Akiko Hatori، نويسنده , , Kazuhiko Yanamoto، نويسنده , , Masanao Ogawa، نويسنده , , Gukuto Ito، نويسنده , , Chika Odawara، نويسنده , , Tomoteru Yamasaki، نويسنده , , Koichi Kato، نويسنده , , Kazutoshi Suzuki، نويسنده ,
Abstract :
Oseltamivir phosphate (Tamiflu®, 1•H3PO4 is an orally active anti-influenza drug, which is hydrolyzed by esterase to its carboxylate metabolite Ro 64-0802 (2) with potent activity inhibiting neuraminidase. In this study, for the first time, we synthesized carbon-11-labeled oseltamivir ([11C]1) and Ro 64-0802 ([11C]2) as two novel positron emission tomography probes and demonstrated that [11C]1 had twofold higher radioactivity concentration in the mouse brains than [11C]2.
