Title of article
Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies
Author/Authors
M?nica D?az-Gavil?n، نويسنده , , José A. G?mez-Vidal، نويسنده , , Fernando Rodr?guez-Serrano، نويسنده , , Juan A. Marchal، نويسنده , , Octavio Caba، نويسنده , , Antonia Ar?nega، نويسنده , , Miguel A. Gallo، نويسنده , , Antonio Espinosa-de-los-Monteros، نويسنده , , Joaqu?n M. Campos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1457
To page
1460
Abstract
Completing a SAR study, a series of (RS)-1- or 3-(1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and (RS)-6-substituted-7- or 9-(1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-7H- or 9H-purines have been prepared. Their antiproliferative activities on MCF-7 cells are here presented and discussed. (RS)-6-Chloro-9-[1-(9H-9-fluorenylmethoxycarbonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-9H-purine (28) is the most active (IC50 = 0.67 ± 0.18 μM) of the series so far described. cDNA microarray technology reveals potential drug targets, which are mainly centred on apoptosis regulatory pathway genes.
Keywords
Benzoxazepines , MCF-7 cell line , Microarrays , purines , pyrimidines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799186
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