Title of article :
Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata
Author/Authors :
Malcolm S. Buchanan، نويسنده , , Anthony R. Carroll، نويسنده , , Annette Edser، نويسنده , , Melissa Sykes، نويسنده , , Gregory A. Fechner، نويسنده , , Paul I. Forster، نويسنده , , Gordon P. Guymer، نويسنده , , Ronald J. Quinn، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC50 of 0.36 μM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.
Keywords :
Carboxypeptidase B (CPB) , natural products , Lysiana subfalcata , Structure elucidation , NMR spectroscopy , Small molecule inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
