Title of article
Novel methylene-linked heterocyclic EP1 receptor antagonists
Author/Authors
Adrian Hall، نويسنده , , Rino A. Bit، نويسنده , , Susan H. Brown، نويسنده , , Anita Chowdhury، نويسنده , , Gerard M.P. Giblin، نويسنده , , David N. Hurst، نويسنده , , Ian R. Kilford، نويسنده , , Xiao Lewell، نويسنده , , Alan Naylor، نويسنده , , Tiziana Scoccitti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
1592
To page
1597
Abstract
We describe the SAR, in terms of heterocyclic replacements, for a series of pyrazole EP1 receptor antagonists. This study led to the identification of several aromatic heterocyclic replacements for the pyrazole in the original compound. Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series.
Keywords
Pyrazole , EP1 antagonist , isostere , Heterocycle
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799213
Link To Document