Title of article :
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold
Author/Authors :
Mohane Selvaraj Coumar، نويسنده , , Jian-Sung Wu، نويسنده , , Jiun-Shyang Leou، نويسنده , , Uan-Kang Tan، نويسنده , , Chung-Yu Chang، نويسنده , , Teng-Yuan Chang، نويسنده , , Wen-Hsing Lin، نويسنده , , John T.-A. Hsu، نويسنده , , Yu-Sheng Chao، نويسنده , , Su-Ying Wu، نويسنده , , Hsing-Pang Hsieh، نويسنده ,
Abstract :
Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.
