Author/Authors :
Francisco Cuenca، نويسنده , , Olga Greciano، نويسنده , , Mekala Gunaratnam، نويسنده , , Shozeb Haider، نويسنده , , Deeksha Munnur، نويسنده , , Rupesh Nanjunda، نويسنده , , W. David Wilson، نويسنده , , Stephen Neidle، نويسنده ,
Abstract :
A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.
