Title of article
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol
Author/Authors
Liming Shao، نويسنده , , Michael Hewitt، نويسنده , , Thomas P. Jerussi، نويسنده , , Frank Wu، نويسنده , , Scott Malcolm، نويسنده , , Paul Grover، نويسنده , , Kevin Fang، نويسنده , , Patrick Koch، نويسنده , , Chris Senanayake، نويسنده , , Nandkumar Bhongle، نويسنده , , Seth Ribe، نويسنده , , Roger Bakale، نويسنده , , Mark Currie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
1674
To page
1680
Abstract
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.
Keywords
Tramadol , opioids , Metabolic stability
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799229
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